Clinical & Translational Research Ethics Conference

February 20, 2008

Introduction: The Role of Ethics in Advancing our Capacity for Clinical and Translational Research at CCHMC and UC
Speakers: Richard Ittenbach, PhD; Ardythe Morrow, PhD

Engaging the community
Robert Nelson, MD, PhD: Exploring Ethical Issues in Pediatric Translational Research
At the end of this presentation, participants will be able to:

• Describe the challenge of establishing a sufficient prospect of direct benefit to justify translational clinical research in children before adults

Consulting with the community on ethical issues in genetic and pharmacogenomic research
Speaker: John Lynch, PhD
At the end of this presentation, participants will be able to

• Describe common ways that lay communities communicate concerns about ethical issues related to genetics and pharmacogenomics

Consent for research in the acute setting and exception from informed consent (EFIC)
Speaker: Christopher Lindsell, PhD
At the end of this presentation, participants will be able to

• Apply the principles of research ethics to recruiting subjects in emergency, life threatening situations

Community outreach
Speaker: Christopher Bolling, MD
At the end of this presentation, participants will be able to

• Explain common ethical and logistical challenges in translational research regarding community initiatives

Research and vulnerable populations
Ethical issues in HIV research
Speaker: Michael Lyons, MD
At the end of this presentation, participants will be able to

• List key ethical issues in HIV research
• Recognize the role of vulnerable populations in HIV research

Patients lacking the capacity to consent
Speaker: Douglas Mossman, MD
At the end of this presentation, participants will be able to

• Discuss the potential barriers faced by researchers who wish to obtain consent from decisionally impaired subjects

The role of race in research
Speaker: Koffi Maglo, PhD
At the end of this presentation, participants will be able to

• Describe the epistemic status of the concept of race in human population genetics

Ethics and regulations
Identifying and Managing Investigator Conflict of Interest
Speaker: Thomas Boat, MD
At the end of this presentation, participants will be able to

• Recognize the situations that most frequently represent conflicts of interest in human research and options used to responsibly manage this

The Role of the IRB in relation to research ethics
Speakers: Robert W. Frenck, Jr. MD; Melissa Colbert, PhD
At the end of this presentation, participants will be able to

• Discuss the relationship between ethical principles and federal regulations
• Describe how the IRB applies ethical principles in reviewing human subjects’ research

Inmaculada deMelo-Martin, PhD: The role of research ethics consultation in academic health centers
At the end of this presentation, participants will be able to

• Explain why collaboration between research ethicists and scientists is important for academic health centers