Gene-Targeted Mouse Service

1. Purpose: 
   Design and construction of gene targeting vectors
   Targeting of mouse genes into embryonic stem (ES) cells for gene deletions or mutations.
   Injection of targeted ES cells into mouse blastocyst for the production of mice carrying gene deletions or mutations.
   
   
   
2. Location: 

   Gene Targeting Mouse Service Core

   University of Cincinnati

   Department of Molecular Genetics, Biochemistry and Microbiology

   Room 2151 MSB and Room 2051 MSB, ML# 0524

   231 Albert Sabin Way

   Cincinnati, OH 45267 

   
   
   
3. Director: 
   • Dr. Yinhuai Chen (Vector Services)
   • Email: escore@uc.edu
   • Phone: 1-513-558-5314
   • Room Location: MSB 2051
   Tina Grisham (Gene Targeting and Blastocyst injection)
   Email: escore@uc.edu
   Phone: 1-513-4351
   Room Location: MSB 2155
   
   
   
4. Fee structure: 

   Call or email for current price list.

   
   
   
5. Frequency of use: 
   45% University of Cincinnati and Cincinnati Children's Hospital
   55% Academic investigators nationwide.
   
   
   
6. Accessible: 

   To all funded investigators

   
   
   
7. Website:  http://molgen.uc.edu/index.php?level2=corefacilities&level3=corefacilities_gene